Rector Advisor, Vice Dean, and Faculty Member - Istanbul Kent University, Faculty of Pharmacy, Departmant of Pharmocology Visiting Researcher&Lecturer - University College London, Mechanical Engineering and Faculty of Medicine, UK Visiting Lecturer - University of Aveiro, Faculty of Biomedical Engineering, Portugal
"Resveratrol helps protect both your health and skin with the antioxidant power of nature."
Resveratrol is a polyphenolic compound naturally found in grapes, peanuts, blackberries, and some plants. It is known for its antioxidant properties and serves as the plants' defense mechanism against harmful external factors. Resveratrol can reduce oxidative stress in the body, preventing damage in cells. In recent years, it has gained popularity, especially for its heart health benefits and anti-aging effects.
What are the health benefits of resveratrol?
Resveratrol exhibits antioxidant, anti-inflammatory, and anticancer effects. It is particularly known for supporting cardiovascular health, reducing bad cholesterol levels, and decreasing plaque* formation in arteries. Additionally, resveratrol helps regulating blood sugar and increasing insulin sensitivity. There are studies indicating that resveratrol can protect brain cells in neurodegenerative diseases, particularly Alzheimer’s disease and Parkinson by slowing their progression.
*Plaque: These are structures that form on the inner surface of the blood vessels and narrow the vessels.
What are the free radical scavenging and antioxidant effects of resveratrol?
Free radicals are molecules that cause oxidative stress in cells, leading to aging, DNA damage, and various chronic diseases. Resveratrol can neutralize these free radicals, preventing cellular damage.
Its antioxidant effects suppress reactions that harm the cell membrane, proteins, and DNA. By activating antioxidant enzymes in cells, it strengthens natural defense mechanisms, thus slowing cellular aging and helping the prevention of oxidative stress-related diseases like heart disease, diabetes, and neurodegenerative disorders.
Additionally, resveratrol's antioxidant effects on skin health are notable as it can repair damage caused by UV rays and environmental stress, preventing the formation of wrinkles and fine lines.
Resveratrol is considered an important antioxidant that protects cell health and contributes to overall health by reducing the harmful effects of free radicals.
What are the effects of resveratrol on heart health?
Resveratrol is known for its positive effects on heart health. Studies show that it can reduce the risk of coronary heart disease. Its antioxidant properties prevent plaque formation in arteries and inhibit the oxidation of LDL (bad) cholesterol, helping to prevent conditions like arteriosclerosis and blockage. Resveratrol also aids in widening blood vessels, improving blood flow, and lowering blood pressure, while reducing inflammation, which can lower the risk of heart attacks. Research suggests that regular resveratrol supplementation can strengthen cardiovascular health and lower the risk of heart disease.
How does resveratrol play a role in fighting cancer?
Resveratrol’s anticancer effects have drawn attention in various studies. By regulating cell growth, resveratrol can inhibit the proliferation of cancer cells and slow tumor growth. Its antioxidant nature reduces DNA damage, preventing the formation of cancer cells. Resveratrol can trigger apoptosis (programmed cell death) in cancer cells. Research on breast, colon, and prostate cancers suggests that resveratrol can inhibit the growth of these cancer types. It may also help reduce the side effects of chemotherapy and radiotherapy in cancer patients.
How can resveratrol help with neurological diseases?
Resveratrol's effects on brain health have garnered much interest in recent years. Its antioxidant and anti-inflammatory properties can protect brain cells, slowing the progression of neurodegenerative diseases like Alzheimer’s disease and Parkinson. Resveratrol may prevent plaque accumulation in the brain, combating memory loss and cognitive dysfunction. Additionally, it boosts brain cell energy cycle, helping to prevent nerve cell damage. Many studies show that resveratrol improves blood circulation in the brain, helping preserve cognitive functions and preventing age-related cognitive decline.
What are the effects of resveratrol against diabetes?
Resveratrol plays a supportive role in treating type 2 diabetes by helping blood sugar level regulation. It reduces insulin resistance, making the body more sensitive to insulin. Additionally, resveratrol is thought to improve pancreas function by reducing inflammation and oxidative stress. This increases insulin production and enables better blood sugar management. Studies have shown improvements in blood sugar and insulin levels in diabetic patients taking resveratrol supplements. It may also help preventing vascular damage caused by diabetes and reduce diabetes-related complications.
What are the anti-inflammatory effects of resveratrol?
In addition to its antioxidant properties, resveratrol is a polyphenol compound with notable anti-inflammatory effects. These properties make it a supportive agent in the treatment of many inflammation-related diseases. Inflammation develops as an immune response of the body and underlies many chronic diseases. Resveratrol acts as a regulatory mechanism in these processes by inhibiting some biochemical pathways that regulate inflammatory responses, such as NF-kB, which is one of the main factors triggering inflammation. Resveratrol suppresses this complex and reduces the production of inflammatory substances, helping limit inflammation in the body.
What are the antimicrobial effects of resveratrol?
Resveratrol has been shown to be effective against various microorganisms, including bacteria, viruses, fungi, and parasites. Its antimicrobial effects are associated with its ability to support cellular defense mechanisms.
Against bacterial infections, resveratrol can particularly be effective against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. It is thought that it inhibits bacterial growth by weakening cell membrane’s integrity or disrupting their energy metabolism.
It has also been found to have an antiviral effect against viruses. It has been reported to be especially effective against viral pathogens such as influenza and herpes viruses. It prevents the spread of infections by suppressing the replication (multiplication) of viruses.
Resveratrol’s destructive effect on the fungi and parasites is also remarkable. It has been observed that it has antifungal effects against fungi such as Candida albicans, and antiparasitic properties against some types of parasites.
With its broad-spectrum antimicrobial effects, resveratrol offers a natural defense mechanism against different types of infections.
*Antimicrobial: An antimicrobial substance is defined as a substance that inhibits the development of microbes, including bacteria and mold, prevents their growth, and protects against them.
What is the use of resveratrol in cosmetic products?
Resveratrol is widely used in skincare products for its antioxidant and anti-aging properties. It helps protecting the skin from free radicals and reducing signs of aging. It may repair damage caused by the sun exposure and increase skin elasticity. Resveratrol-containing creams and serums help combat fine lines and wrinkles as well.
How does resveratrol benefit the skin?
Resveratrol reduces oxidative stress in the skin, slowing down aging signs and making the skin appear brighter, firmer, and younger. Due to its anti-inflammatory properties, it can also reduce redness and sensitivity. Furthermore, resveratrol supports collagen production in the skin, enhancing elasticity and reducing wrinkles.
Is resveratrol effective in treating acne?
Yes, resveratrol’s anti-inflammatory properties can help treating acne. It balances skin’s oil production, preventing clogged pores. Additionally, it can inhibit the growth of bacteria that cause acne and help to reduce post-acne scars.
What are the protective effects of resveratrol against sun damage?
The harmful UV rays from the sun can damage skin cells and accelerate signs of aging. Resveratrol neutralizes free radicals caused by sun exposure, protecting skin cells. It also activates skin repair mechanisms, helping repair skin damage after sun exposure.
What are the anti-aging effects of resveratrol?
Resveratrol prevents cellular damage caused by free radicals and slows the aging process. Its antioxidant properties reduce the appearance of fine lines and wrinkles, even out skin tone, and make the skin appear firmer. By increasing collagen production, resveratrol supports skin elasticity and helps maintain a youthful appearance.
Does resveratrol have any side effects?
Resveratrol is generally considered a safe compound; however, high doses may cause stomach discomfort or digestive issues. It should be cautiously used together with blood-thinning medications. In cosmetic products, it usually does not cause allergic reactions, but users with sensitive skin may experience redness or irritation.
How is resveratrol used?
Resveratrol can be used orally as a dietary supplement and/or topically in skincare products. Oral supplements are typically recommended for both general and skin health while skincare products like creams and serums are applied to the skin to protect against sun damage, wrinkles and fine lines formation. It is particularly included in the creams and serums designed for night-time usage.
What products contain resveratrol?
Resveratrol is commonly found in anti-aging creams, serums, sunscreens, and acne treatments. It is also available as food supplements in capsule, tablet, and syrup forms. Resveratrol-containing skincare products are used to achieve younger-looking skin and reduce the harmful effects of sun exposure.
Chan CM, et al., Protective effects of resveratrol against UVA-induced damage in ARPE19 cells. (2015).
Cui B, et al., Resveratrol treats UVB-induced photoaging by anti-MMP expression, through anti-inflammatory, antioxidant, and antiapoptotic properties, and treats photoaging by upregulating VEGF-b expression. (2022).
Docherty JJ, et al., Resveratrol inhibition of Propionibacterium acnes. (2007).
Galiniak S, et al., Health benefits of resveratrol administration. (2019).
Guerrero R, et al., Resveratrol, wine and Mediterranean diet: A review. (2009).
Kuršvietienė L, et al., Multiplicity of effects and health benefits of resveratrol. (2016).
Leis K, et al., Resveratrol as a factor preventing skin aging and affecting its regeneration. (2022).
Meng X, et al., Health benefits and molecular mechanisms of resveratrol: A narrative review. (2020).
Opie LH and Lecour S, The red wine hypothesis: from concepts to protective signaling molecules. (2007).
Ratz-Łyko A and Arct J, Resveratrol as an active ingredient for cosmetic and dermatological applications: A review. (2019).
Salehi B, et al., Resveratrol: A double-edged sword in health benefits. (2018).
Shaito A, et al., Potential adverse effects of resveratrol: A literature review. (2020).
Singh AP, et al., Health benefits of resveratrol: Evidence from clinical studies. (2019).
Taylor EJ, et al., Resveratrol demonstrates antimicrobial effects against Propionibacterium acnesin vitro. (2014).
Wei Z, et al., Resveratrol ameliorates lipid accumulation and inflammation in human SZ95 sebocytes via the AMPK signaling pathways in vitro. (2021).
Zhou DD, et al., Effects and mechanisms of resveratrol on aging and age-related diseases. (2021).
