The phrase “12-week pill” usually refers to common DAA treatment durations. Many DAA regimens are prescribed for about 8–12 weeks in certain patient groups, but the duration is not fixed for everyone. Cirrhosis status, prior treatment history, clinician selection, and drug interactions can change the plan. The goal is not simply the shortest course, but the safest strategy that maximizes the chance of SVR. Duration should be determined by a clinician after proper evaluation.