Supplement–drug interactions are a key safety topic. With sedatives, drowsiness may increase. With blood-pressure drugs, blood pressure may drop further. With diabetes medications, blood sugar changes may occur. With thyroid medications, hormone balance may shift, so thyroid patients should be extra cautious. If you use immunosuppressants, medical advice is important. With antidepressants or anxiety medications, clinician review is strongly recommended due to nervous-system effects. If you take regular medication, do not add ashwagandha (or any supplement) without guidance from a clinician or pharmacist.