Modern hepatitis C treatment is based on oral direct-acting antivirals (DAAs), typically used in combination regimens. These drugs target key viral proteins required for replication and aim to achieve sustained virologic response (SVR), which is considered a functional cure. The right regimen depends on clinical variables such as cirrhosis status, prior treatment history, kidney function, and potential drug–drug interactions. Therefore, there is no single “best” medication for everyone; selection is individualized and should be clinician-guided. These are prescription medications and require medical supervision.