Timing should be planned based on your goal and tolerance. For sleep support, many people take it after dinner or one to two hours before bedtime, which may help relaxation and nighttime muscle comfort. If the goal is daytime muscle tension or a higher total dose, splitting the dose (morning/evening) can improve tolerability and steadier coverage. If you have a sensitive stomach, taking it with food is often better than on an empty stomach. Magnesium can also reduce absorption of certain medications if taken at the same time (for example, thyroid medication, some antibiotics, or bisphosphonates), so spacing by a few hours is a practical safety rule. The “best” time is the one you can follow consistently without side effects—consistency beats perfect timing.