There is no single universal “danger threshold,” because different metrics are used. In practice, clinicians interpret HOMA-IR, fasting insulin, and fasting glucose together. Some labs provide reference ranges for HOMA-IR, but values should be read in context—age, body composition, waist circumference, HbA1c, and triglyceride/HDL profile matter. If HbA1c is rising or fasting glucose shifts into the prediabetes range, the risk profile becomes more urgent and requires tighter lifestyle execution plus clinical follow-up. The most reliable approach is not locking onto one number, but tracking trends over time: repeat labs every 3–6 months, monitor waist changes, and integrate symptoms. For safety and accuracy, define targets with internal medicine or endocrinology guidance rather than self-interpreting isolated values.