In recent years, peptides, a popular ingredient in anti-aging care, stimulate collagen production, increase skin elasticity, and reduce the appearance of wrinkles. This helps the skin appear plumper and firmer. With regular use, in addition to its anti-aging effect, it strengthens the skin's natural barrier and provides protection against external factors.
What is a peptide?
Peptides are the building blocks of essential proteins such as collagen and elastin found in our skin. These amino acid chains contribute to the natural functioning of the skin and have gained popularity in recent years. Naturally found in the body, peptide production decreases with aging, leading to concerns like fine lines, loss of elasticity, and dryness. External factors such as irregular sleep and unhealthy nutrition can also reduce peptide levels in the body.
When and how should peptide serums be used?
Peptide-containing serums are generally applied to clean, dry skin in the morning and/or evening. A moisturizer is then applied on top. If a toner is used in the skincare routine, the peptide serum should be applied after the toner. It is crucial to apply the peptide serum before the moisturizer to allow it to penetrate the deeper layers of the skin and enhance the benefits of the moisturizer. The most effective usage is when combined correctly with other active ingredients in the routine.
What are the benefits of peptides on the skin?
Peptides stimulate collagen and elastin production, helping prevent fine lines and delay aging. They support maintaining a firm and smooth skin appearance and contribute to a plumper look. They also aid in repairing and strengthening the skin barrier, contribute to an even skin tone, soothe redness and inflammation, and help control acne.
Which skin types are peptides suitable for?
Peptides are suitable for all skin types, including sensitive, dry, oily, and acne-prone skin. They are generally safe for almost everyone and do not usually cause allergies or side effects.
Can peptide serums be used every day?
Peptide-containing serums can be used daily, and regular use increases the effectiveness of the product.
Can peptides be used together with retinol?
Peptides and retinol are two different ingredients that both stimulate collagen synthesis and complement each other in skincare. Many products combine these two to create a synergistic effect. However, there are important considerations for their joint use. They can be used together in a nighttime routine or alternately to avoid intolerance—for example, using peptides during the day and retinol at night.
Which ingredients should not be used with peptides?
Peptide serums should not be used at the same time as serums containing multiple acid blends. They should not be used with AHA and BHA acids like glycolic acid and salicylic acid, as these acids can break peptide bonds, reducing effectiveness or increasing skin sensitivity.
With which active ingredients does the effect of peptides increase when combined?
Peptides can be safely used with many active ingredients. When combined with the following, their effects are enhanced:
With retinol: provides a strong anti-aging effect, increases skin elasticity, and reduces fine lines.
With hyaluronic acid: enhances skin regeneration and moisture levels, leading to a plumper and healthier appearance.
With vitamin C and other antioxidants: supports collagen production like peptides and enhances the anti-aging effect.
With niacinamides: moisturizing properties may boost the collagen-supporting effects of peptides.
Are peptides good for acne?
Some peptide molecules also have antimicrobial properties, which may help prevent acne-causing bacteria, thereby reducing inflammation and redness and aiding skin repair.
What should we consider when buying a peptide serum?
Not every skin needs the same type of peptide. First, one must determine which peptide form is appropriate for specific needs such as increased elasticity, reduced wrinkles, barrier repair, acne scar reduction, or hydration support. Another important factor is that the peptide serum should be able to penetrate the outer layer of the skin and reach active layers like the epidermis and dermis. Always choose peptide products backed by clinical research.
Can peptides be used during pregnancy and breastfeeding?
Peptides can be safely used during pregnancy and breastfeeding. Since retinoids are strictly prohibited during pregnancy, peptides can be a beneficial alternative for anti-aging effects. However, if you have any concerns, consult your doctor before use.
Are peptides suitable for sensitive skin?
Yes, they are. If your skin is sensitive and inflamed, peptides may help reduce visible swelling by increasing the production of a group of anti-inflammatory compounds known as prostaglandins, which helps reduce redness.
What is the current position of peptides in consumers’ skincare routines?
Peptide ingredients are increasingly prominent in consumers' skincare routines. “In 2019, peptides were present in 13% of consumers’ skincare routines. In 2023, they were included in 26% of routines. Peptides are expected to be the fastest-growing active ingredient over the next 5 years.” — Kline & Co Market Research (2023)
Pintea A, et al., Peptides: emerging candidates for the prevention and treatment of skin senescence: a review. Biomolecules 2025.
Aguilar-Toalá JE, et al., Potential role of natural bioactive peptides for development of cosmeceutical skin products. Peptides 2019.
Ledwoń P et al., Peptides as Active Ingredients: A Challenge for Cosmeceutical Industry. Chem Biodivers 2021.
Peptides are taking the skin care world by storm in 2024.