Bromelain is often tolerated, but side effects vary by dose and individual factors. Common issues are gastrointestinal (heartburn, nausea, abdominal pain, diarrhea, gas). Allergic reactions can occur, especially in people with pineapple allergy or cross-reactivity (e.g., latex/pollen). A key concern is bleeding risk and interactions with anticoagulants/antiplatelets and some NSAIDs or herbal products. Easy bruising, gum/nose bleeding warrants stopping and medical review. Before surgery or dental procedures, clinicians may advise discontinuation. Always check labels and interactions.