Yes. Some people develop gastrointestinal symptoms—especially with large single doses or sensitive stomachs—including bloating, cramps, gas, and diarrhea. Practical fixes include splitting the dose, taking it with meals, starting low, and staying well hydrated. Product form and additives also matter; sweeteners in flavored products can worsen tolerance. If symptoms persist, stop the supplement and consider other causes (food intolerance, infection, medications). People with chronic gut conditions or multiple supplements should use professional guidance.