Depression is a multi-factor condition with biological, psychological, and social components, so it cannot be “treated” with a single supplement. Magnesium supports nervous system regulation and stress-response pathways, so some individuals may notice indirect improvements in sleep, tension, or overall well-being—especially if they had low magnesium intake to begin with. Correcting a deficiency can support general health, but this is not a guaranteed antidepressant effect and does not replace evidence-based care.

If depressive symptoms are present—loss of interest, hopelessness, appetite or sleep changes, impaired concentration—the priority is clinical evaluation. Supplements should be considered only as supportive additions. Safety also matters: interactions with medications, dosing, and kidney function should be taken into account. The most effective framework is integrated: evidence-based treatment (therapy and/or medication), lifestyle fundamentals (sleep, movement, nutrition), and targeted micronutrient support when appropriate.