Timing is less important than tolerability and product content. Pure bromelain is not a stimulant, so bedtime use can be acceptable for some. However, it may cause GI discomfort in sensitive individuals, which can disrupt sleep. Combination products with caffeine/thermogenics can also impair sleep or cause palpitations. There is no strong evidence that bedtime provides special “edema” benefits. If trying it, test tolerance during daytime first and adjust based on your response.