Vitamin D and vitamin C can generally be taken together; there is no standard rule that they cannot be combined in the general population. Their absorption pathways differ: vitamin D is fat-soluble and is best absorbed with a meal that contains fat, while vitamin C is water-soluble and can be consumed at various times of day.\n\nWhat matters most is purpose and dose management. Vitamin D is often planned based on blood levels under clinical guidance, whereas vitamin C is commonly achievable through diet. If you use high-dose vitamin C, consider personal risks such as gastrointestinal sensitivity or a history of kidney stones. On the vitamin D side, unnecessarily high doses can increase toxicity risk.\n\nPractical guidance: take vitamin D with a fat-containing main meal, and obtain vitamin C through produce distributed across the day. If you supplement, align dosing with label guidance and your overall daily intake, and consult a clinician or pharmacist if you have chronic conditions or complex regimens.