MELATONIN & SLEEP: SCIENCE-BACKED, PLAIN-LANGUAGE GUIDE “Panic often feeds on a cycle of stress and poor sleep.” Melatonin does not directly treat panic attacks. Panic disorder involves anxiety loops, stress physiology, and the interpretation of bodily sensations as dangerous. However, sleep deprivation and circadian disruption can worsen anxiety; if melatonin improves sleep regularity, some people may experience indirect relief. A critical caveat: if you wake suddenly at night with palpitations, sweating, or breathlessness, medical causes (sleep apnea, reflux, thyroid issues, arrhythmias) should also be considered. Melatonin should not mask symptoms or delay evaluation. Primary treatments for anxiety and panic include psychotherapy (especially CBT), breathing/relaxation strategies, lifestyle changes, and medication when clinically indicated. Melatonin may play a supportive role for sleep rhythm, but if it increases restlessness, nightmares, or awakenings, discontinue and seek professional advice.