First, clarity: there is no “magnesium glycinate deficiency.” The deficiency is magnesium as a mineral. Symptoms are not specific and can overlap with many other conditions. Muscle twitches, cramps, restlessness, fragmented sleep, stress sensitivity, fatigue, and headaches may appear with low magnesium intake, but they do not confirm deficiency by themselves. The most reliable approach is clinical evaluation and laboratory assessment. Serum magnesium does not always reflect total body stores perfectly, so clinicians interpret results in context. Also, vitamin D deficiency, low iron stores (ferritin), low B12, thyroid dysfunction, sleep disorders, and chronic stress can mimic similar symptoms. Therefore, instead of random high-dose supplementation, the safer strategy is: measure, rule out key drivers, and build a targeted plan.