Clinical risk is usually assessed using creatinine and eGFR—not “creatine.” There is no single universally “dangerous” creatinine number because age, sex, muscle mass, hydration, and lab methods matter. That is why clinicians interpret creatinine together with eGFR and urine albumin/protein. A muscular person may have a higher baseline creatinine, while an older person with low muscle mass may show a “normal” creatinine despite reduced eGFR. Risk becomes more meaningful when creatinine rises rapidly, eGFR declines, urine albumin/protein is present, or symptoms occur (swelling, reduced urine output, shortness of breath). The goal is kidney protection through medical and lifestyle management rather than chasing a single lab value.