Folic acid can generally be taken at any time of day; consistency matters more than the exact hour. If you have stomach sensitivity, taking it with food may be more comfortable. In preconception planning, the operational goal is daily adherence with a sustainable routine. If you are also managing B12, timing can be coordinated based on clinician or dietitian guidance. The “best” time is the one you can follow reliably. If you have specific medical conditions or medication interactions, personalize timing with professional input.