Diuretics are prescription medications and timing depends on the specific drug and the patient’s clinical context. Many are scheduled earlier in the day to avoid night-time urination, but this is individualized. Using diuretics or “water-loss” supplements without understanding the cause of edema can be risky (electrolyte imbalance, low blood pressure, palpitations, kidney effects). Bromelain is not a diuretic medication. Persistent or sudden edema warrants medical evaluation and tailored treatment.