Edema has many causes (salt, hormones, sleep, prolonged sitting, medications, circulation issues, inflammation), so there is no universal “best time.” Some people use bromelain as supportive care in swelling/inflammation contexts, but the underlying cause matters more than timing. If the stomach is sensitive, taking it with or after meals may be better tolerated. Recurrent or sudden edema should be evaluated medically, especially with red-flag symptoms. Lifestyle factors (salt-water balance, movement, sleep) remain the foundation.