The healthiest orthopedic mattress depends on the individual, but the key factor is proper spinal support. A healthy mattress should fill the natural curve of the lower back while allowing controlled pressure relief at the shoulders and hips. Extremely firm mattresses can prevent muscle relaxation, whereas overly soft mattresses may cause spinal misalignment. Medium-firm mattresses that evenly distribute body weight are often considered the healthiest choice. Material quality, breathability, and durability also play an important role. A healthy mattress helps reduce morning stiffness and supports overall sleep quality.