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What Is Urınary Tract Infectıon? What Are Its Symptoms? What Medıcınes Are Used In Its Treatment? What Are Alternatıve Herbal Support Products?

Rector (Urologist) – Istanbul Kent University
Rector Advisor, Vice Dean, and Faculty Member - Istanbul Kent University, Faculty of Pharmacy, Departmant of Pharmocology
Visiting Researcher&Lecturer - University College London, Mechanical Engineering and Faculty of Medicine, UK
Visiting Lecturer - University of Aveiro, Faculty of Biomedical Engineering, Portugal

"Early diagnosis and appropriate treatment are important, as urinary tract infections (UTI, cystitis) can lead to serious complications, such as kidney damage and sepsis, if left untreated."

İdrar Yolu Enfeksiyonu Nedir? Belirtileri, Tedavisi Ve Bitkisel Destek Ürünleri Nelerdir?

What is an Urinary Tract Infection (UTI)?

A urinary tract infection (UTI) is an infection that can occur in any part of the urinary system, especially in the lower urinary tract such as the bladder* and urethra**. The most common cause is the bacterium Escherichia coli (E. coli), which typically comes from the intestines. UTIs are more common in women than in men because women have a shorter urethra, which is closer to the anus, making it easier for bacteria to reach the bladder. UTI can range from a simple bladder infection (cystitis) to more severe infections that can spread to the kidneys. 

*Bladder: An organ that stores urine excreted from the kidneys and is part of the urinary system.

**Urethra: The name of the tube that exits the bladder and mediates the urine to be excreted from the body.

***Anus: The exit hole at the end of the digestive system where feces are excreted.

What are the Main Symptoms of UTI?

Symptoms of a UTI include a frequent urge to urinate, a burning sensation during urination, blood in the urine or cloudy urine, pain or pressure in the lower abdomen, and foul-smelling urine. In more severe cases, especially if the infection has spread to the kidneys, symptoms may include fever, chills, nausea, vomiting, and severe pain in the sides of the back. In some groups, such as children and the elderly, symptoms may be non-classical (atypical), so careful attention is required.

What Medications are Used in UTI Treatment?

The most commonly used medications for treating UTIs are antibiotics, which kill or inhibit the growth of bacteria. Common antibiotics include trimethoprim-sulfamethoxazole, nitrofurantoin, and fosfomycin. Quinolone antibiotics (e.g. ciprofloxacin) are still frequently used today, even though bacteria have developed high rates of resistance. The duration of treatment depends on the severity of the infection and the patient's overall health. In some cases, treatment may include broad-spectrum antibiotics if the bacteria are resistant.

What Methods Can Be Used to Prevent UTI?

Personal hygiene is key in preventing UTIs. Urinating after sexual intercourse can help prevent bacteria from entering the urinary tract. Additionally, drinking plenty of water and not holding in urine for long periods can reduce the risk of infection. Women are advised to wipe from front to back after using the toilet. In cases of frequent recurrent UTIs, preventive antibiotic therapy under medical supervision may be considered.

What is the Relationship Between Sexual Activity and UTI?

Sexual activity, especially in women, can increase the risk of UTI. This is because bacteria can more easily enter the urethra during intercourse. Frequent sexual activity, engaging with a new partner, or using spermicides as part of contraception can increase the risk of UTI. Urinating after intercourse is an effective method to reduce this risk.

What are the Risks of UTI During Pregnancy?

UTI during pregnancy can lead to serious health issues for both the mother and the baby. Pregnancy increases the risk of UTI due to hormonal changes and the growing uterus putting pressure on the urinary tract. If left untreated, the infection can spread to the kidneys, leading to undesirable effects (complications) such as preterm labor or miscarriage. Therefore, pregnant women should be vigilant for UTI symptoms and undergo regular prenatal check-ups.

How are UTIs in Children Understood and Treated?

UTI symptoms in children may differ from those in adults, making diagnosis challenging. Infants may present with irritability, feeding difficulties, or unexplained fever. Older children may complain of burning during urination, abdominal pain, or frequent urination. Treatment typically involves age-appropriate doses of antibiotics, and families should be educated on hygiene and fluid intake to prevent recurrence. Circumcision at an early age in males is also seen as a preventive measure against UTI. Vesicoureteral reflux is a common disease in children who have UTIs. This disease, which is quite common among infants and children, can lead to permanent kidney damage and increase the risk of chronic UTI if it progresses.

What is the Relationship Between Antibiotic Resistance and UTI?

The frequent use of antibiotics, particularly in treating common infections like UTIs, can lead to the development of antibiotic resistance. This means that bacteria become resistant to antibiotics, making treatment more difficult. In treating UTI, careful selection of antibiotics is necessary, and, if possible, antibiotic sensitivity testing should be performed. Over-the-counter use of antibiotics should be strictly avoided.

What are the Complications After UTI?

Untreated or inadequately treated UTIs can lead to various undesirable effects (complications). Infections that spread to the kidneys (pyelonephritis) can cause serious health problems. Kidney damage, sepsis, and chronic kidney disease are some of the severe complications that can be prevented with timely and appropriate treatment. Additionally, in cases of frequent UTI, underlying structural or functional issues should be investigated.

What are the Herbal Products that Support UTI Treatment?

There are herbal supplements that can be used as a supplement alongside antibiotics or as an alternative with a doctor's advice in cases where there is an allergy to the active ingredient in the antibiotic. Cranberry extract can prevent bacteria from adhering to the urinary tract. Probiotics, especially Lactobacillus species, may help prevent the recurrence of UTI. However, the effectiveness of these herbal treatments is less proven compared to antibiotics, and they should only be used under medical guidance.

Commonly Known Misconceptions

Urinary tract infection (UTI) is a widely known but often misunderstood health issue. Here are some of the most common misconceptions:

"UTIs only occur in women."

False. While UTIs are more common in women due to their anatomy, men can also experience them. Older men, especially those with prostate issues, are at increased risk of developing UTIs.

"UTIs are only sexually transmitted."

False. Although sexual activity can increase the risk of UTIs, the infection itself is not exclusively transmitted through sexual contact. UTIs are usually caused by bacteria like E. coli, which travel from the intestines to the urinary tract. Sexual activity may facilitate this process but is not the primary cause.

"Drinking plenty of water cures UTIs."

False. While drinking water can help reduce the risk of UTIs and alleviate symptoms, it cannot treat an existing infection. Antibiotics are necessary to completely eradicate the infection. Water can help flush out bacteria but is not sufficient for a cure.

"UTIs will go away on their own."

False. Untreated UTIs can lead to more serious conditions, such as kidney infections (pyelonephritis), which can cause lasting damage. If you suspect a UTI, it is important to consult a doctor for proper treatment.

"Burning during urination always indicates a UTI."

False. While a burning sensation during urination is a common symptom of UTIs, it can also be caused by other health conditions, such as vaginal infections, sexually transmitted diseases, or bladder irritation. It is important to consult a doctor for an accurate diagnosis.

  1. Flores-Mireles AL, et al. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769054/

  2. Foxman B, et al. Urinary tract infection in postmenopausal women: Incidence and risk factors. (2020). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328492/

  3. Medina M, et al. Urinary tract infections: epidemiology and pathogenesis. (2022). https://link.springer.com/article/10.1007/s00248-020-01505-0

  4. Liss MA, et al. Acute uncomplicated cystitis in women: A systematic review and meta-analysis. (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858649/

  5. Gupta K, et al. Emerging concepts in the management of recurrent urinary tract infections. (2020). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409933/

  6. Hooton TM, et al. Recurrent urinary tract infection in women: Diagnosis and management. (2020). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383462/

  7. Jepson RG, et al. Cranberries for preventing urinary tract infections. (2020). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389531/

  8. Foxman B, et al. Probiotics and urinary tract infection: An overview of clinical trials. (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142078/

  9. Raz R, et al. Urinary tract infection prevention and treatment strategies. (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272526/

  10. Wagenlehner FM, et al. Prevention of recurrent urinary tract infections: Evidence-based guidelines. (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7975607/

  11. Platt R, et al. Sexual activity and urinary tract infections. (2020). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518123/

  12. Johnson JR, et al. Prevention of urinary tract infection after sexual intercourse. (2022). https://link.springer.com/article/10.1007/s00192-020-04552-8

  13. Epp A, et al. Urinary tract infection in pregnancy. (2021). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253425/

  14. Kouri T, et al. Urinary tract infections during pregnancy: Management and outcome. (2020).

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