Compared with vitamins A and D, toxicity from dietary vitamin K1/K2 is uncommon. However, supplementation can be problematic in specific contexts—most importantly for people taking warfarin, where higher vitamin K intake may lower INR and reduce anticoagulant effect, potentially increasing clot risk. Some individuals may experience mild gastrointestinal upset. If using D3+K2 combinations, remember that excessive vitamin D can raise hypercalcemia risk; dosing and follow-up should be deliberate.