Eye fatigue most commonly comes from the combination of prolonged near work and environmental stress. With screens, reading, and detail-heavy tasks, the eye sustains accommodative effort while blink rate tends to drop. Fewer blinks accelerate tear evaporation, amplifying dryness—and dryness can drive burning, redness, intermittent blur, and light sensitivity. Glare, suboptimal lighting, incorrect prescription, irregular sleep, dry air/AC, and extended contact lens wear can intensify symptoms. Reduce strain through system-level adjustments: keep a reasonable working distance; position the screen slightly below eye level; minimize glare; increase font size; use scheduled breaks (20-20-20 is a useful framework); and practice complete blinking during intense focus. If symptoms are recurrent, check for refractive errors—small prescription issues can trigger end-of-day headaches and ocular discomfort. If fatigue is accompanied by one-sided severe pain, sudden vision changes, flashes/floaters with “curtain” symptoms, marked redness with discharge, or trauma, it may be more than simple strain and should be evaluated promptly by an eye professional.