There is no single “best time” for postbiotics; timing depends on the formulation and your goal. People with sensitive stomachs often tolerate them better with food. Some prefer mornings as part of a routine, while others take them later in the day for gut-comfort goals. More important than the clock is consistency—taking the product at roughly the same time daily makes effects easier to track. If your goal is post-antibiotic recovery, whether to use it during antibiotics or after can be product-specific, so label instructions and professional advice matter. For immune-support goals, a multi-week, consistent protocol is often more rational than sporadic use. Remember: outcomes are not independent of diet and lifestyle—fiber intake, sleep quality, and stress management shape the baseline. If you take medications (especially anticoagulants or immune-modulators), consult a clinician/pharmacist about how to position supplements in your day.