There is no single “magic vitamin” for eye health—evidence favors an overall dietary pattern and correct clinical indication. For the general population, the most robust strategy is a nutrient-dense diet with colorful produce (especially dark leafy greens), adequate protein, healthy fats, and avoiding smoking. The retina and macula are vulnerable to oxidative stress, so antioxidants and carotenoids (lutein and zeaxanthin) are widely studied. But supplementation is not a one-size-fits-all recommendation. A key exception is age-related macular degeneration (AMD). The AREDS/AREDS2 trials showed that specific formulations can reduce the risk of progression to advanced AMD in selected risk groups. The crucial point is “the right formula for the right patient.” AREDS2-type supplements are not meant for everyone with eye discomfort; they are most relevant when an eye professional identifies AMD risk/stage where benefit is supported. Supplements are not drugs; product quality varies, and certain ingredients warrant caution depending on smoking history and medical context. A practical framework: (1) optimize lifestyle (UV protection, sleep, metabolic control such as glucose and blood pressure), (2) get an eye exam for risk stratification, (3) if indicated, choose an evidence-based formula and dose. For many people, the “best eye vitamin” is consistent intake of leafy greens + omega-3 sources + overall micronutrient adequacy; supplementation should be a targeted clinical decision.