Citicoline is generally well tolerated, but not for everyone. Avoid it if you have a known allergy to citicoline or any excipients. If you use regular medications, consider interactions—especially dopaminergic therapy (e.g., levodopa), where monitoring for additive effects may be needed.\n\nPregnancy and breastfeeding: evidence is limited, so do not start without clinician approval. In children, age and dosing depend on product and indication; use only with pediatric guidance.\n\nIf you have bipolar disorder/mania history, severe insomnia/anxiety, uncontrolled hypertension, significant arrhythmias, or epilepsy, a careful risk–benefit assessment is recommended.\n\nBottom line: decision-making should be individualized, especially when comorbidities or medications are present.