With topical agents like clascoterone, the most common side effects are local irritation and barrier sensitivity: redness, burning/stinging, dryness, scaling, and itching can occur. These effects are often manageable by adjusting application frequency, using a suitable moisturizer, and avoiding harsh concurrent products (e.g., alcohol-based toners, strong exfoliants). In rare cases, significant dermatitis, eczema flare, or allergic reactions may occur—if so, discontinue and seek medical advice. As with any topical therapy, avoid contact with eyes and mucous membranes. For individuals who are pregnant/breastfeeding, have endocrine conditions, or use multiple medications, individualized clinical guidance becomes more important.