Winlevi is commonly known as a topical cream containing clascoterone and is used for acne vulgaris as an androgen receptor–targeted approach. In acne, two major drivers are excess sebaceous activity and inflammation; clascoterone aims to reduce local androgen signaling in the skin, which may help address both pathways. In real-world use, success depends on consistency, protecting the skin barrier with appropriate moisturization, adjusting frequency if irritation occurs, and using a personalized combination plan when indicated. Results typically appear gradually over several weeks. Early dryness or sensitivity can occur with many topical acne therapies. If severe irritation, eczema flare, or unexpected reactions develop, stop and seek clinical guidance.