There is no single “best” reflux medication for everyone; the right choice depends on symptom severity and risk of tissue injury. For mild, occasional symptoms, antacids can provide quick relief. For more frequent symptoms, H2 blockers may help, especially for nighttime issues. For GERD that occurs multiple days per week, significantly affects quality of life, or suggests esophagitis, proton pump inhibitors (PPIs) are often the most effective class. The operating principle is correct indication, appropriate duration, and lifestyle optimization in parallel. Persistent need for medication can signal unmanaged triggers or alternative diagnoses (functional heartburn, bile reflux, eosinophilic esophagitis). For longer-term plans, clinician-guided strategy is the safest and most effective path.